The clinical assessment and therapeutic strategy focused on analyzing and correcting the timing and amplitude of cortisol secretion throughout the day. Unlike a simple single-point measurement, sequencing involves collecting multiple samples to map the full 24-hour pattern, which is essential for diagnosing HPA axis dysfunction. The goal is to restore the optimal, healthy diurnal curve to support energy, mood, and sleep quality.
Origin
This advanced clinical practice is a direct evolution of understanding the Cortisol Diurnal Variation, moving from mere observation to active diagnostic and therapeutic intervention. “Sequencing” implies the ordered, time-based nature of the assessment and the precision of the targeted intervention.
Mechanism
The sequencing process identifies deviations, such as a flattened curve or an inverted rhythm, which reflect chronic stress or adrenal fatigue. Therapeutic strategies involve timed administration of specific nutrients, adaptogens, or occasionally low-dose hormones to signal the hypothalamus and pituitary. This aims to re-entrain the adrenal glands to the proper circadian rhythm, thereby normalizing the body’s stress response.
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