What is the Origin of Cortisol Rhythm Integrity?

The concept originates from the study of the HPA axis, the central stress response system, and the glucocorticoid hormone cortisol. The term "rhythm" highlights the chronobiological nature of cortisol release, a key regulatory signal synchronized with the sleep-wake cycle. Disruptions to this integrity are classic indicators of chronic stress, sleep disturbance, or adrenal dysfunction, impacting systemic homeostasis.

What is the Mechanism of Cortisol Rhythm Integrity?

The integrity of the rhythm is maintained by the pulsatile release of Corticotropin-Releasing Hormone (CRH) from the hypothalamus, stimulating Adrenocorticotropic Hormone (ACTH) release from the pituitary, which subsequently drives cortisol synthesis and secretion. A robust negative feedback loop controls the amplitude and timing of these pulses. Loss of integrity often involves blunted or inverted diurnal curves, reflecting dysregulation at the central or peripheral level.

Cortisol Rhythm Integrity

Meaning

Cortisol Rhythm Integrity describes the state of a healthy, predictable, and synchronized diurnal pattern of cortisol secretion from the adrenal cortex, regulated by the hypothalamic-pituitary-adrenal (HPA) axis. This integrity is characterized by a sharp morning peak (Cortisol Awakening Response), a gradual decline throughout the day, and the lowest concentration around midnight. Maintenance of this rhythm is paramount for optimal stress adaptation, immune regulation, and metabolic health.