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Cortisol Rhythm Fragmentation

Meaning

Cortisol Rhythm Fragmentation refers to a pathological disruption of the normal, smooth, and predictable diurnal curve of cortisol secretion, resulting in an erratic pattern characterized by numerous, high-frequency, or uncoordinated peaks and troughs throughout the day. This unstable pattern is a stark contrast to the healthy, integrated circadian variation. Clinically, this fragmentation is a key indicator of chronic, unmanaged stress, profound sleep deprivation, or severe HPA axis dysregulation. Such instability compromises systemic regulation, often leading to persistent fatigue, mood disturbances, and metabolic inefficiency.