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Cortisol Rhythm Fidelity

Meaning

Cortisol Rhythm Fidelity is the clinical term for the precise adherence of an individual’s daily cortisol secretion pattern to the established, healthy circadian rhythm. This rhythm is characterized by a sharp morning peak, a gradual decline throughout the day, and the lowest levels occurring before and during sleep. High fidelity indicates a robust, healthy Hypothalamic-Pituitary-Adrenal (HPA) axis response. It is a key biomarker of stress adaptation.