Cortisol Rhythm Fidelity is the clinical term for the precise adherence of an individual’s daily cortisol secretion pattern to the established, healthy circadian rhythm. This rhythm is characterized by a sharp morning peak, a gradual decline throughout the day, and the lowest levels occurring before and during sleep. High fidelity indicates a robust, healthy Hypothalamic-Pituitary-Adrenal (HPA) axis response. It is a key biomarker of stress adaptation.
Origin
This term is derived from chronobiology and endocrinology, specifically relating to the measurement of the Cortisol Awakening Response (CAR) and the diurnal curve. The word “Fidelity” is used to denote the accuracy and reliability of the pattern compared to the biological norm. This concept is central to assessing adrenal function.
Mechanism
Maintaining high fidelity in the cortisol rhythm is crucial for regulating energy, metabolism, and immune function. Disruption, often seen as an inverted or flattened curve, indicates chronic stress or HPA axis dysregulation. Restoring this pattern helps to re-establish proper sleep architecture, optimize glucose regulation, and improve the body’s adaptive response to daily stressors.
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