What is the Origin of Cortisol Reversal?

This descriptive term arises directly from clinical observation and laboratory analysis of the cortisol diurnal curve, indicating a functional reversal of the expected physiological pattern. It is often correlated with chronic HPA axis stress and maladaptation.

What is the Mechanism of Cortisol Reversal?

Chronic, unremitting stress can lead to a desensitization or dysregulation within the HPA axis feedback loop, disrupting the central circadian signal from the SCN. The sustained elevation of cortisol during the evening inhibits the release of melatonin and impairs restorative sleep, further perpetuating the cycle of neuroendocrine imbalance and metabolic stress.

Cortisol Reversal ∞ Area

Cortisol Reversal

Meaning

Cortisol reversal is a pathological pattern observed in clinical endocrinology where the normal diurnal rhythm of cortisol secretion is inverted. Instead of the typical morning peak and evening decline, the patient exhibits lower morning and disproportionately higher evening or nighttime cortisol levels.