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Cortisol Response Gating

Meaning

Cortisol Response Gating describes the precise physiological mechanism that regulates the magnitude and duration of the cortisol release from the adrenal glands in reaction to a stressor. This gating mechanism is crucial for ensuring a sufficient, yet not excessive, glucocorticoid response to maintain systemic homeostasis without causing damage from prolonged exposure. Clinical interventions often aim to optimize this gating function to prevent chronic HPA axis dysregulation, which is a common driver of metabolic and immune issues. An effectively gated response ensures resilience and rapid recovery from acute stress.