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Cortisol Pathways

Meaning

Cortisol pathways refer to the complex sequence of biochemical synthesis, regulation, transport, and catabolism that govern the life cycle of the primary human glucocorticoid, cortisol. These pathways are fundamentally orchestrated by the Hypothalamic-Pituitary-Adrenal (HPA) axis, which controls the pulsatile release of the hormone in a circadian rhythm. Clinically, a comprehensive assessment of these pathways, including free and metabolized cortisol measurements, provides insight into an individual’s chronic stress adaptation and overall metabolic health. Dysregulation in any part of this system is directly linked to conditions like adrenal fatigue, metabolic syndrome, and mood disorders.