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Cortisol Nadir Management

Meaning

Cortisol Nadir Management refers to the clinical strategy focused on optimizing the timing and magnitude of the lowest point in the diurnal cortisol rhythm, which typically occurs late at night or around midnight. The cortisol nadir is a critical physiological marker, signifying the necessary rest and repair phase of the HPA axis before the morning surge. Disruptions, such as an inappropriately high or low nocturnal nadir, are correlated with sleep disturbances, chronic stress states, and impaired immune function. Effective management aims to restore this minimum to a healthy, predictable low level.