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Cortisol Metabolite Profiling

Meaning

Cortisol Metabolite Profiling is an advanced endocrine laboratory technique that measures not only the parent stress hormone cortisol but also its downstream, biologically inactive metabolites, such as tetrahydrocortisol (THF) and tetrahydrocortisone (THE), in biological samples. This comprehensive assessment provides a detailed view of total cortisol production, as well as the efficiency of its hepatic clearance and conversion by key enzymes like 5-alpha and 5-beta reductases. This profiling offers a nuanced understanding of the Hypothalamic-Pituitary-Adrenal (HPA) axis activity and its systemic impact on health.