What is the Origin of Cortisol Melatonin Inversion?

This marker is critical in clinical assessments of HPA axis dysfunction, often signaling chronic stress adaptation.

What is the Mechanism of Cortisol Melatonin Inversion?

Chronic activation of the HPA axis due to persistent stressors can dysregulate the suprachiasmatic nucleus, leading to a failure in the reciprocal morning surge of cortisol and evening rise of melatonin.

Cortisol Melatonin Inversion ∞ Area

Cortisol Melatonin Inversion

Meaning

Cortisol Melatonin Inversion describes the pathological reversal of the expected diurnal rhythm, where evening cortisol remains high and nighttime melatonin is suppressed.

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