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Cortisol Mediated Antagonism

Meaning

Cortisol Mediated Antagonism describes the inhibitory or counter-regulatory effects that chronically elevated or dysregulated cortisol exerts on other critical endocrine axes, primarily the reproductive and thyroid systems. This is a fundamental survival mechanism where the body, perceiving a threat, temporarily suppresses non-essential functions to conserve energy for immediate defense. Clinically, this antagonism manifests as suppressed testosterone or estrogen levels, diminished thyroid hormone conversion, and reduced sensitivity at target tissues, profoundly impacting metabolic rate, fertility, and mood. Recognizing this hormonal cross-talk is key to comprehensive treatment strategies.