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Cortisol Interference Mechanism

Meaning

Cortisol Interference Mechanism describes the pathological process where chronically elevated or inappropriately timed cortisol disrupts the normal signaling and function of other essential hormones and physiological systems. This interference is not merely additive but a complex, competitive, or suppressive action at the cellular receptor level and through systemic feedback loops. The clinical consequence is a cascade of hormonal imbalances, including suppression of the thyroid axis and reduced sensitivity to sex steroids. Understanding this mechanism is key to resolving seemingly disparate endocrine symptoms.