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Cortisol-Insulin Sensitivity Dynamics

Meaning

Cortisol-insulin sensitivity dynamics refers to the complex, bidirectional interplay between the stress hormone cortisol and the metabolic hormone insulin, specifically concerning the responsiveness of peripheral tissues to insulin signaling. Cortisol, a glucocorticoid, generally acts antagonistically to insulin, promoting glucose production and inhibiting glucose uptake in many tissues. The balance of these two hormones is crucial for maintaining stable blood glucose levels and overall metabolic health. Chronic disruption of this dynamic is a key feature of metabolic syndrome.