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Cortisol Influence Epigenetics

Meaning

Cortisol influence epigenetics describes the capacity of the stress hormone cortisol to induce long-lasting changes in gene expression without altering the underlying DNA sequence. This mechanism involves modifying the chemical tags on DNA or histone proteins, effectively switching genes on or off in a manner that can be sustained even after the cortisol stimulus is removed. Clinically, persistent or aberrant cortisol signaling is understood to drive epigenetic remodeling, contributing to the pathophysiology of chronic stress-related conditions. This hormonal impact represents a critical intersection between the endocrine system and the regulatory machinery of the genome.