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Cortisol Induced Elastosis

Meaning

A specific form of dermal connective tissue degeneration characterized by the accumulation of abnormal, non-functional elastic material in the dermis, directly resulting from chronic, elevated levels of the glucocorticoid hormone cortisol. This pathological process leads to a clinical presentation of thin, fragile skin with increased laxity and a predisposition to bruising and striae formation. It is a recognized dermatological sequela of sustained hypercortisolism, whether endogenous or exogenous in origin.