Skip to main content

Cortisol Impact Attenuation

Meaning

Cortisol impact attenuation describes the clinical and physiological strategy of reducing the overall negative influence or intensity of cortisol’s effects on target tissues, particularly when the hormone is persistently elevated or dysregulated due to chronic stress. This approach does not aim to eliminate cortisol, which is essential for life, but rather to mitigate the detrimental consequences of excessive or poorly timed glucocorticoid signaling on metabolic, immune, and cognitive health. It represents a therapeutic goal in managing chronic stress and HPA axis dysfunction.