What is the Origin of Cortisol Hypersecretion?

The term is a clinical compound derived from 'Cortisol,' the specific hormone produced in the adrenal cortex, and 'Hypersecretion,' combining the Greek prefix hyper- meaning "over" or "excessive," with secretio, the Latin for "separation" or "release." It clearly denotes an overproduction of this stress hormone.

What is the Mechanism of Cortisol Hypersecretion?

The primary mechanism involves chronic overactivation of the Hypothalamic-Pituitary-Adrenal (HPA) axis, where the hypothalamus continuously releases corticotropin-releasing hormone (CRH). This prompts the pituitary to release excessive adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal glands to synthesize and secrete elevated cortisol. The normal negative feedback loop becomes less sensitive or overwhelmed, perpetuating the state of chronic hypercortisolemia.

Cortisol Hypersecretion ∞ Area

Cortisol Hypersecretion

Meaning

Cortisol hypersecretion is the pathological or persistent physiological condition characterized by the adrenal cortex releasing an excessive amount of the glucocorticoid hormone cortisol into the systemic circulation. This chronic elevation, often a response to prolonged psychological or physiological stress, disrupts the normal diurnal rhythm of the hormone. Sustained hypersecretion is clinically linked to detrimental effects on metabolism, immune function, and bone density.