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Cortisol Glucocorticoid Suppression

Meaning

Cortisol Glucocorticoid Suppression is the pharmacological or physiological action of intentionally reducing the synthesis or activity of cortisol, the primary human glucocorticoid, typically in response to a state of chronic hypercortisolemia. While cortisol is vital for stress response and metabolism, chronically elevated levels can lead to adverse effects like immune dysfunction, muscle wasting, and central adiposity. This suppression is a targeted therapeutic strategy to mitigate the deleterious effects of persistent stress on the endocrine system. The clinical goal is to restore a healthy diurnal rhythm and normalize overall glucocorticoid signaling.