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Cortisol Dysregulation Impact

Meaning

Cortisol Dysregulation Impact describes the cascade of adverse physiological and metabolic consequences that result from an abnormal pattern of cortisol secretion, whether characterized by chronic excess, sustained deficiency, or a loss of the normal diurnal rhythm. This impact extends across multiple organ systems, affecting glucose homeostasis, immune surveillance, inflammatory pathways, and the integrity of the hypothalamic-pituitary-gonadal (HPG) axis. Clinically, this dysregulation is a central driver of chronic stress-related pathologies, contributing to abdominal adiposity, poor sleep quality, bone density loss, and mood disorders. Addressing the dysregulation is paramount for restoring systemic hormonal balance and vitality.