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Cortisol Dysregulation Assessment

Meaning

Cortisol dysregulation assessment is a specialized clinical methodology used to precisely evaluate deviations from the normal, rhythmic secretion and metabolism of the hormone cortisol. This goes beyond merely measuring absolute levels to determine if the pattern of cortisol release—the diurnal curve—is flattened, inverted, or excessively high or low at specific times. Identifying dysregulation is paramount because it signals a functional imbalance within the Hypothalamic-Pituitary-Adrenal (HPA) axis, often preceding overt disease. This nuanced evaluation helps pinpoint the physiological stage of stress response or adrenal fatigue.