Cortisol Dynamics and Recovery describes the temporal pattern of cortisol secretion—its diurnal rhythm, magnitude of response to acute stress, and the speed at which levels return to baseline post-challenge. Optimal dynamics are characterized by high morning peaks and rapid nocturnal decline, reflecting a responsive yet resilient HPA axis.
Origin
This terminology is standard in clinical endocrinology and chronobiology, specifically analyzing the Hypothalamic-Pituitary-Adrenal (HPA) axis function. The “recovery” aspect emphasizes the system’s ability to return to homeostasis after perturbation.
Mechanism
Dynamics are governed by the HPA axis feedback loop, where CRH and ACTH drive adrenal output of cortisol, which then negatively feeds back to the hypothalamus and pituitary. Efficient recovery relies on the swift de-sensitization of these central receptors and the clearance of circulating glucocorticoids. Poor recovery indicates chronic allostatic load, potentially leading to metabolic dysregulation.
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