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Cortisol Dominance Syndrome

Meaning

Cortisol Dominance Syndrome is a functional endocrine pattern characterized by an imbalance where the catabolic effects of elevated or inappropriately timed cortisol outweigh the protective and anabolic effects of other hormones, such as DHEA and sex steroids. This state does not necessarily imply Cushing’s disease but rather a functional, stress-induced dysregulation of the HPA axis. The resulting biochemical environment promotes protein breakdown, fat deposition, and immune suppression, significantly impacting overall health and body composition.