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Cortisol Diurnal Curve Modulation

Meaning

The intentional adjustment or normalization of the naturally occurring, 24-hour rhythmic fluctuation in cortisol levels, often achieved through lifestyle interventions or targeted pharmacologic agents. Cortisol levels typically peak shortly after waking and gradually decline throughout the day, reaching their nadir near midnight; this pattern is the diurnal curve. Clinical modulation aims to restore this optimal circadian rhythm when stress or pathology has caused dysregulation, thereby supporting better stress resilience and sleep quality.