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Cortisol DHEA-S Ratio Analysis

Meaning

This clinical diagnostic tool involves calculating the mathematical relationship between the circulating levels of cortisol, the primary glucocorticoid stress hormone, and DHEA-sulfate (DHEA-S), a major adrenal androgen and precursor hormone. The resulting ratio provides a snapshot of the body’s overall adrenal reserve and its ability to manage chronic physiological stress. An altered ratio can signify adrenal fatigue, excessive stress burden, or an imbalance in the body’s anabolic-to-catabolic hormonal state.