What is the Origin of Cortisol Dampening?

This practice developed from clinical observations of sustained hypercortisolemia associated with chronic stress and its pathological sequelae, including visceral adiposity and immune suppression. The term "dampening" implies a refinement of the stress response system rather than a complete shutdown. It is rooted in the understanding of negative feedback inhibition within the HPA axis.

What is the Mechanism of Cortisol Dampening?

Dampening mechanisms often involve strengthening the negative feedback loop exerted by cortisol on the hypothalamus and pituitary gland, making them less sensitive to CRH and ACTH stimulation, respectively. Furthermore, supporting precursors and cofactors for cortisol metabolism and receptor function can influence the overall set point. Modulating neurotransmitter systems that influence HPA axis excitability also contributes significantly to this physiological attenuation.

Cortisol Dampening ∞ Area

Cortisol Dampening

Meaning

Cortisol Dampening is a targeted clinical strategy aimed at reducing the amplitude or frequency of excessive cortisol secretion, particularly in the context of chronic stress-induced HPA axis hyperactivity. This is not about eliminating cortisol, which is essential, but rather attenuating the hyper-responsiveness of the hypothalamic-pituitary-adrenal axis to perceived threats. The desired outcome is a normalization of the diurnal cortisol curve, reducing nighttime elevation and morning blunting. This modulation is key to improving sleep and reducing systemic inflammation.