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Cortisol Curve

Meaning

The Cortisol Curve is the graphical representation of the diurnal variation in circulating cortisol levels, typically measured across a 24-hour period. This essential endocrine rhythm, known as the Circadian Rhythm of Cortisol, is characterized by a sharp peak shortly after waking and a gradual decline throughout the day, reaching its nadir around midnight. Clinical assessment of this curve provides crucial diagnostic information regarding adrenal function and HPA axis integrity. Deviations from the expected pattern, such as a flattened or inverted curve, are often indicative of chronic stress or adrenal dysfunction, impacting overall systemic health.