What is the Origin of Cortisol Clearance Rates?

This concept is derived from pharmacokinetic principles applied specifically to endogenous glucocorticoids like cortisol. 'Clearance' refers to the theoretical volume of plasma cleared of the substance per unit time. Understanding this rate is essential for interpreting serum cortisol levels relative to secretion dynamics.

What is the Mechanism of Cortisol Clearance Rates?

The primary mechanism involves hepatic enzymatic hydroxylation and subsequent conjugation of cortisol into inactive metabolites, which are then excreted renally. Alterations in liver function or the induction/inhibition of key metabolizing enzymes directly modify this rate. Faster clearance can lead to functional cortisol deficiency despite adequate adrenal output.

Cortisol Clearance Rates ∞ Area

Cortisol Clearance Rates

Meaning

The kinetic measurement describing the speed at which circulating cortisol, the primary glucocorticoid, is metabolized and eliminated from the systemic circulation. This rate reflects the functional capacity of hepatic enzymes, primarily those in the Cytochrome P450 system, involved in steroid catabolism. Clinical assessment of clearance helps differentiate between production and elimination disorders.