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Cortisol Circadian Rhythm Normalization

Meaning

This clinical objective involves therapeutic and lifestyle interventions aimed at restoring the natural, cyclical pattern of cortisol secretion throughout the 24-hour day, which is often disrupted by chronic stress or illness. Normalization means achieving the characteristic peak in the early morning to promote wakefulness and the subsequent gradual decline throughout the day, reaching its nadir around midnight. Maintaining this rhythm is fundamental for proper sleep-wake cycles, immune regulation, and overall metabolic health.