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Cortisol Burden Reduction

Meaning

Cortisol Burden Reduction is a clinical objective focused on actively mitigating the overall physiological impact of chronically elevated or dysregulated cortisol exposure on the body’s tissues and endocrine axes. This strategy targets the cumulative stress load on the hypothalamic-pituitary-adrenal (HPA) axis, aiming to restore a healthy diurnal cortisol rhythm and improve tissue sensitivity to other hormones. Successful reduction is critical for reversing catabolic states, preserving bone density, and improving immune and metabolic function. Chronic cortisol excess is a significant driver of aging and disease.