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Cortisol Buffer Capacity

Meaning

Cortisol Buffer Capacity describes the physiological resilience of the hypothalamic-pituitary-adrenal (HPA) axis and peripheral tissues to manage acute and chronic stressors without leading to significant dysregulation of the cortisol rhythm or downstream systemic pathology. It represents the functional reserve that allows the body to absorb a stressor-induced surge in cortisol and return rapidly to baseline homeostatic balance. A high buffer capacity indicates a robust stress response system, which is crucial for maintaining metabolic and immune integrity under duress. Diminished capacity, conversely, suggests vulnerability to stress-related hormonal imbalance and potential adrenal fatigue symptoms.