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Cortisol Axis Profiling

Meaning

Cortisol Axis Profiling is the precise clinical assessment of the Hypothalamic-Pituitary-Adrenal (HPA) axis function through the measurement of cortisol and related metabolites over a defined time period, often utilizing multiple samples to capture the diurnal rhythm. This profiling reveals the body’s adaptive capacity to stress and helps identify dysregulation patterns, such as blunted morning response or evening elevation, which can impact sleep and immune function. It provides a detailed functional map of the primary stress-response system.