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Cortisol Axis Buffering

Meaning

Cortisol Axis Buffering refers to therapeutic strategies and physiological adaptations designed to modulate the intensity and duration of the body’s stress response, primarily governed by the Hypothalamic-Pituitary-Adrenal (HPA) axis. The clinical objective is to maintain a healthy, adaptive cortisol release pattern while preventing chronic hyper- or hypo-cortisolemia. This buffering mechanism protects peripheral tissues from the damaging catabolic effects of prolonged stress hormone exposure. It is a critical component of metabolic resilience.