Question 1

What is the Meaning of Cortisol Axis Assessment?

Accepted Answer

Cortisol Axis Assessment is a comprehensive diagnostic procedure used to evaluate the functional integrity and rhythmic activity of the Hypothalamic-Pituitary-Adrenal (HPA) axis, the body's central stress response system. This assessment typically involves measuring cortisol levels in biological fluids, such as saliva or serum, at multiple, precise time points throughout a 24-hour period. The clinical objective is to identify patterns of dysregulation, such as a flattened circadian rhythm or inappropriate total output, which are often correlated with chronic stress or adrenal fatigue states. This detailed profile provides actionable data for targeted HPA axis support.

Question 2

What is the Origin of Cortisol Axis Assessment?

Accepted Answer

The basis of Cortisol Axis Assessment is rooted in classical endocrinology and the discovery of the HPA axis and its negative feedback loops, a system formalized by Hans Selye's work on the General Adaptation Syndrome. The shift to a rhythmic assessment, rather than a single point-in-time measurement, emerged from the understanding that cortisol's pulsatile, diurnal secretion is more clinically relevant than its absolute concentration. Salivary and four-point testing techniques advanced the field by offering non-invasive, practical methods for capturing this dynamic pattern.

Question 3

What is the Mechanism of Cortisol Axis Assessment?

Accepted Answer

The assessment operates by quantifying the unbound, biologically active fraction of cortisol that diffuses into the tested biological matrix over the course of the day. A healthy mechanism shows a high morning peak followed by a gradual decline throughout the day, reaching a nadir before sleep. Dysregulation mechanisms, such as chronic stress, can lead to persistent high levels or an exhausted, flattened curve, reflecting an impaired feedback loop or diminished adrenal reserve. The results allow clinicians to pinpoint the specific phase of HPA axis dysfunction.

Cortisol Axis Assessment

Meaning

Origin

Mechanism

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