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Cortisol Antagonism of Anabolism

Meaning

Cortisol Antagonism of Anabolism describes the direct inhibitory effect of the stress hormone cortisol on the body’s constructive metabolic processes, specifically protein synthesis and tissue building (anabolism). This is a critical regulatory function where cortisol, as a powerful catabolic agent, actively opposes the beneficial actions of anabolic hormones like testosterone and growth hormone. Understanding this antagonism is essential for addressing muscle wasting, impaired recovery, and bone demineralization observed in states of high or prolonged physiological stress. It represents a fundamental conflict in metabolic regulation.