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Cortical Volume Integrity

Meaning

Cortical Volume Integrity refers to the preservation of the physical size and structural health of the cerebral cortex, the brain’s outer layer responsible for higher-level functions like memory, language, and consciousness. Clinically, maintaining this integrity is a key metric in longevity and hormonal health, as age-related hormonal decline can contribute to cortical thinning and atrophy. It is a quantifiable measure of brain health, often assessed via neuroimaging, that correlates directly with sustained cognitive function. Preserving cortical volume is a primary goal of neuroprotective strategies.