What is the Origin of Cortical Thickness Maintenance?

The concept originates in structural neuroimaging and developmental neuroscience, where cortical metrics are used to assess brain health across the lifespan. Its inclusion here links systemic hormonal balance directly to central nervous system architecture.

What is the Mechanism of Cortical Thickness Maintenance?

Maintenance is achieved through balancing synaptic plasticity processes, including both long-term potentiation and pruning, which are modulated by circulating hormones. For example, adequate estrogen and testosterone signaling supports neuronal membrane integrity and dendritic arborization, counteracting age-related atrophy. Furthermore, efficient thyroid hormone signaling ensures appropriate gene regulation for neuronal survival pathways.

Cortical Thickness Maintenance ∞ Area

Cortical Thickness Maintenance

Meaning

Cortical Thickness Maintenance refers to the preservation of the gray matter volume in the cerebral cortex, a metric strongly associated with long-term cognitive reserve and resilience against neurodegeneration. Optimal hormonal milieu, particularly involving neurosteroids and thyroid hormones, is a key determinant of this structural integrity.

$A fractured branch displays raw wood, representing hormonal imbalance and metabolic dysfunction. Resilient lichen and moss signify cellular repair and endocrine recovery, illustrating the patient journey towards hormone optimization.$