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Cortical Remodeling

Meaning

Cortical remodeling, in the context of skeletal health, refers to the continuous, coordinated process of bone tissue turnover occurring primarily in the dense outer layer of bone, known as the cortex. This mechanism involves the resorption of old or damaged bone by osteoclasts and the subsequent formation of new bone matrix by osteoblasts. Maintaining a favorable balance in cortical remodeling is crucial for preserving bone strength, density, and resistance to fracture throughout the lifespan. Hormonal factors, notably parathyroid hormone and sex steroids, are key regulators of this dynamic equilibrium.