What is the Origin of Corneocyte Transport Mechanism?

This term stems from detailed dermatological and pharmaceutical research focused on elucidating the structure-function relationship of the skin barrier, often described by the "brick-and-mortar" model. Corneocytes, the 'bricks,' were recognized as a potential transport route, especially for highly lipophilic molecules that favor partitioning into cellular structures. The study of this transport is integral to maximizing overall drug absorption through the skin.

What is the Mechanism of Corneocyte Transport Mechanism?

Transport via the corneocyte involves the compound passing sequentially through the lipid cell membrane, the intracellular keratin-rich matrix, and the subsequent inner cell membrane. Highly lipophilic hormones may favor this pathway due to their affinity for the cellular components. The rate of transcellular transport is governed by the compound's solubility within the intracellular keratin and its ability to traverse the dense cellular environment, a pathway generally slower than the intercellular route.

Corneocyte Transport Mechanism ∞ Area

Corneocyte Transport Mechanism

Meaning

The specific physiological process detailing how therapeutic molecules move through the corneocytes, the terminally differentiated, protein-filled cells that form the skin’s protective stratum corneum layer. This mechanism, known as the transcellular route, is an alternative to the primary intercellular lipid pathway. Understanding the efficiency of this transport is vital for designing effective topical and transdermal formulations for hormonal compounds. It represents a significant challenge due to the dense cellular structure.