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Coregulators

Meaning

A class of non-DNA-binding proteins that interact directly with nuclear receptors, such as the Androgen Receptor or Estrogen Receptor, to modulate the transcriptional activity of target genes. These essential proteins function as either coactivators, which enhance gene expression, or corepressors, which inhibit it, thereby fine-tuning the cellular response to hormonal signals. The balance and specific recruitment of coregulators are critical determinants of the final biological effect of a hormone in a given tissue.