Copper Peptide Bioavailability refers to the degree and rate at which a specific copper-binding peptide, typically Glycyl-L-Histidyl-L-Lysine (GHK-Cu), is absorbed into the systemic circulation or a target tissue and becomes available to exert its biological effects. Clinically, optimizing this parameter is essential to maximize the therapeutic potential of the peptide, particularly its documented roles in tissue remodeling, anti-inflammatory action, and antioxidant defense. The measurement ensures that the administered dose effectively reaches the cellular receptors and enzymatic systems to drive the desired physiological outcome.
Origin
This term is a fusion of the chemical component ‘Copper Peptide’—referencing the small, naturally occurring peptide GHK complexed with copper—and the pharmacological concept of ‘Bioavailability.’ The GHK-Cu peptide was discovered in the 1970s by Dr. Loren Pickart. Its widespread application in wound healing and dermatology has made its systemic and local availability a critical research and clinical focus.
Mechanism
The bioavailability is determined by the peptide’s stability against enzymatic degradation, its solubility, and its ability to traverse biological membranes, such as the skin barrier or the intestinal wall. Once bioavailable, the GHK-Cu complex acts by facilitating the transport of copper ions into cells, where copper is an essential cofactor for numerous enzymes, including superoxide dismutase and lysyl oxidase. This mechanism supports collagen production, angiogenesis, and potent anti-inflammatory and regenerative signaling pathways.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.