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Controlled Ovarian Hyperstimulation

Meaning

Controlled Ovarian Hyperstimulation (COH) is a clinical protocol utilized in reproductive endocrinology to induce the development of multiple ovarian follicles in a single menstrual cycle, significantly increasing the number of oocytes available for retrieval. This therapeutic strategy is a foundational component of assisted reproductive technologies (ART) like In Vitro Fertilization (IVF) and is meticulously managed to optimize the quantity and quality of mature eggs while minimizing the risk of ovarian hyperstimulation syndrome (OHSS). The goal is to overcome common fertility challenges by maximizing the number of viable embryos available for transfer or cryopreservation.