What is the Origin of Controlled Drug Release?

This technology emerged from pharmaceutical science to address the limitations of immediate-release formulations, which often require frequent dosing and can cause transient side effects due to high peak plasma concentrations. The development of polymer science and material engineering in drug delivery provided the technical foundation for these advanced systems.

What is the Mechanism of Controlled Drug Release?

Controlled release is achieved through various physical and chemical mechanisms, including the use of diffusion-controlled matrix systems, dissolution-controlled coatings, or osmotic pressure-driven pumps. These mechanisms ensure that the drug is released at a predictable, predetermined rate, offering a sustained and steady delivery profile that mimics the body's natural physiological needs more closely.

Controlled Drug Release ∞ Area

Controlled Drug Release

Meaning

Controlled Drug Release is a sophisticated pharmaceutical engineering strategy designed to modulate the rate at which an active therapeutic agent is liberated from its dosage form into the systemic circulation over an extended period. The primary clinical goal is to maintain the drug concentration within the optimal therapeutic window for a prolonged duration, minimizing the fluctuations associated with rapid absorption and elimination. This technology improves both efficacy and patient compliance.