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Contraindications

Meaning

Specific conditions, clinical situations, or concurrent factors that render the use of a particular drug, procedure, or therapy inadvisable or potentially harmful to a patient. A contraindication signifies a substantial risk of an adverse outcome that outweighs any potential therapeutic benefit, necessitating a careful clinical assessment before initiating treatment. These factors are meticulously identified during clinical trials and are formally documented in the product’s prescribing information to guide clinical decision-making. Absolute contraindications denote situations where the therapy must never be used, while relative contraindications suggest caution and careful risk-benefit analysis.