What is the Origin of Continuous Progesterone Therapy?

This therapeutic strategy developed from the necessity of mitigating the risks associated with unopposed estrogen replacement therapy, which historically led to increased rates of endometrial pathology. The continuous dosing model contrasts with sequential or cyclic regimens, which are designed to mimic the natural menstrual cycle with periodic withdrawal bleeding. It is a refinement in the clinical application of endocrinology.

What is the Mechanism of Continuous Progesterone Therapy?

The continuous presence of progesterone induces endometrial atrophy, stabilizing the uterine lining and preventing the uncontrolled cell proliferation stimulated by estrogen. Progesterone acts by binding to its nuclear receptors within endometrial cells, triggering transcriptional changes that halt the mitotic effects of estrogen and promote differentiation. This constant regulatory signal ensures a quiescent endometrial state, avoiding the cyclic withdrawal bleed characteristic of sequential hormone therapy.

Continuous Progesterone Therapy ∞ Area

Continuous Progesterone Therapy

Meaning

Continuous Progesterone Therapy is a specific regimen of hormone replacement where a progestogen, typically bioidentical progesterone, is administered daily without interruption, often alongside estrogen therapy. This clinical approach is commonly employed in postmenopausal women with an intact uterus to provide consistent endometrial protection against the proliferative effects of estrogen. The goal is to prevent endometrial hyperplasia and reduce the risk of uterine cancer while managing menopausal symptoms.