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Conjugation Pathways

Meaning

Conjugation pathways represent the crucial Phase II detoxification processes, primarily located in the liver, responsible for converting active, fat-soluble hormone metabolites and environmental toxins into water-soluble compounds. This biochemical transformation involves attaching a highly polar molecule, such as glucuronic acid, sulfate, or glutathione, to the target compound. The resulting conjugated molecule is typically pharmacologically inert and can be readily excreted from the body via bile or urine. Robust function of these pathways is essential for maintaining hormonal homeostasis and preventing the reabsorption of potentially detrimental metabolites.