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COMT Gene Variant

Meaning

A COMT Gene Variant refers to a common polymorphism, often a single nucleotide change (SNP), within the gene that encodes for Catechol-O-Methyltransferase (COMT). This enzyme is critically important for the inactivation and clearance of catecholamines like dopamine and norepinephrine, as well as certain catechol estrogens. The specific genetic variation can significantly impact the enzyme’s activity, leading to altered metabolic rates for these compounds. Clinically, a reduced-activity variant may result in slower clearance, influencing mood stability, pain sensitivity, and the efficiency of estrogen detoxification pathways.