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COMT Activity

Meaning

COMT activity refers to the functional efficiency of the Catechol-O-Methyltransferase enzyme, a critical component in the metabolic clearance of catecholamines, including dopamine, norepinephrine, and epinephrine, as well as catechol estrogens. This enzymatic function is paramount in regulating neurotransmitter levels in the synapse and managing the body’s overall estrogen metabolism, particularly the potentially damaging catechol estrogen metabolites. Individual genetic variations, notably single nucleotide polymorphisms (SNPs), can lead to high or low COMT activity, profoundly influencing mood, pain sensitivity, and hormonal detoxification capacity. Clinical assessment of this activity informs personalized strategies for hormonal balance and neurological support.