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Combined T4/T3 Therapy

Meaning

Combined T4/T3 Therapy is a clinical strategy for managing hypothyroidism that involves administering both levothyroxine (T4) and liothyronine (T3) hormones concurrently. This approach seeks to replicate the physiological hormone profile more closely than T4 monotherapy, which relies solely on the body’s peripheral conversion of T4 to the active T3. The goal is to optimize cellular thyroid hormone signaling, particularly in individuals who may exhibit impaired T4 to T3 conversion pathways. Precise dosing ratios are critical for achieving symptomatic relief and maintaining euthyroid status.