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Combined Estrogen-Progestogen Therapy

Meaning

Combined Estrogen-Progestogen Therapy, often referred to as CEPT or combined MHT, is a standard clinical intervention involving the simultaneous administration of both an estrogen compound and a progestogen compound to women, typically for the management of menopausal symptoms. The inclusion of the progestogen is a crucial clinical necessity for women who still possess a uterus, as it counteracts the proliferative effects of unopposed estrogen on the endometrium, thereby significantly reducing the risk of developing endometrial hyperplasia or carcinoma. This dual-hormone regimen aims to restore a more balanced hormonal profile and alleviate systemic symptoms.