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Collision-Induced Dissociation

Meaning

Collision-Induced Dissociation, or CID, is a critical analytical technique utilized within tandem mass spectrometry for the structural elucidation and precise quantification of complex biomolecules, including steroid hormones and their metabolites. This powerful process fragments an ion of interest into smaller, characteristic daughter ions by introducing kinetic energy. It provides the definitive molecular fingerprint necessary for unambiguous identification in clinical laboratories.